➡️ numerous other associated symptoms (may involve various organs and systems) such as fatigue, stiffness, sleep and gastrointestinal disturbances, anxiety, depression

➡️ Chronic pain and the wide variety of symptoms require accurate differential diagnosis with a number of conditions presenting a common AND / OR concomitant symptom picture

➡️ DD with rheumatic, neurological, infectious, psychiatric, metabolic endocrine diseases

➡️ multidisciplinary approach, biopsychosocial model, patient education, exercise and rehabilitation, self management, lifestyle modification, personalized therapy